A poignard in the breast of the tyrant

[Below is a letter to Dr. Samuel Brown written on July 14, 1813, regarding the remedy for tyranny:]

I shall set great store by the Capsicum, if it is hardy enough for our climate, the species we have heretofore tried being too tender. The Galvance, too, will be particularly attended to, as it appears very different from what we cultivate by that name. I have so many grandchildren and others who might be endangered by the poison plant, that I think the risk overbalances the curiosity of trying it.

The most elegant thing of that kind known is a preparation of the Jamestown weed, Datura-Stramonium, invented by the French in the time of Robespierre. Every man of firmness carried it constantly in his pocket to anticipate the Guillotine. It brings on the sleep of death as quietly as fatigue does the ordinary sleep, without the least struggle or motion. Condorcet, who had recourse to it, was found lifeless on his bed a few minutes after his landlady had left him there, and even the slipper which she had observed half suspended on his foot, was not shaken off. It seems far preferable to the Venesection of the Romans, the Hemlock of the Greeks, and the Opium of the Turks.

I have never been able to learn what the preparation is, other than a strong concentration of its lethiferous principle. Could such a medicament be restrained to self-administration, it ought not to be kept secret. There are ills in life as desperate as intolerable, to which it would be the rational relief, e. g. the inveterate cancer. As a relief from tyranny indeed, for which the Romans recurred to it in the times of the emperors, it has been a wonder to me that they did not consider a poignard in the breast of the tyrant as a better remedy.